Jamie Murphy's goal condemned AFC Bournemouth to their second straight defeat as Sheffield United went top of League One.
Murphey found the net after twenty minutes, striking on the rebound after his initial shot had struck the woodwork.
Lewis Grabbed wasted a great chance for the Cherries in the first half, while Barry Robson saw an early effort come back off the bar.
The defeat is Eddie Howe's first at The Goldands Stadium since he returned for his second spell as Cherries manager.
Ryan Fraser made his debut from the substitutes bench, and Matt Tubbs was also sent on to try and force an equaliser.
The Blades nearly handed the Cherries a point when Harry Maguire's wayward clearance sailed inches over his own crossbar.
The defeat leaves Bournemouth in sixth place in League One, two points behind Sheffield United - who now top the table.